Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis
C. D. Byerly, L. L. Patterson, N. Pittner, R. Solomon, J. Patel, M. R. Rogan, J. W. McBride
This study shows Ehrlichia chaffeensis uses a Wnt-like SLiM to deactivate Hippo signaling, activating Yap and the anti-apoptotic Yap-GLUT1-BCL-xL axis, enhancing infection.
bioRxiv · Mar 6, 2023 · PreprintMicrobiology