Author

L. L. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1 Approach:statistical model· 1

Frequent Co-Authors

J. W. McBride· 4 shared C. D. Byerly· 3 shared J. Patel· 3 shared D. C. Bui· 2 shared N. Pittner· 2 shared R. Solomon· 2 shared S. Paessler· 2 shared T. S. Velayutham· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersMicrobiology

J. W. McBride

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Author profile →

4 papers

Recent·Most cited

Ehrlichia Wnt short linear motif ligand mimetic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis

C. D. Byerly, L. L. Patterson, N. Pittner, R. Solomon, J. Patel, M. R. Rogan, J. W. McBride

This study shows Ehrlichia chaffeensis uses a Wnt-like SLiM to deactivate Hippo signaling, activating Yap and the anti-apoptotic Yap-GLUT1-BCL-xL axis, enhancing infection.

bioRxiv · Mar 6, 2023 · PreprintMicrobiology

Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

J. W. McBride, L. L. Patterson, C. D. Byerly, R. Solomon, N. Pittner, D. C. Bui, J. Patel

This study shows Ehrlichia chaffeensis uses Notch signaling to stabilize XIAP and inhibit apoptosis, enhancing its survival within host cells.

bioRxiv · Jan 6, 2023 · PreprintMicrobiology

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

C. Byerly, S. Mitra, L. L. Patterson, N. A. Pittner, T. S. Velayutham, S. Paessler, V. Veljkovic, J. W. McBride

This study identifies a TRP120 SLiM ligand mimetic from Ehrlichia chaffeensis that activates Hedgehog signaling to induce BCL-2 expression and inhibit apoptosis, facilitating bacterial infection.

bioRxiv · Feb 8, 2022Microbiology

Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

L. L. Patterson, T. S. Velayutham, C. D. Byerly, D. C. Bui, J. Patel, V. Veljkovic, S. Paessler, J. W. McBride

This paper identifies a short linear motif (SLiM) in the Ehrlichia TRP120 effector that mimics Notch ligands to activate Notch signaling in human monocytes.

bioRxiv · Jan 13, 2022Pathology