Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.
M. Misheva, K. Kotzamanis, L. Davies, V. Tyrrell, P. Rodrigues, G. Benavides, H. Christine, R. Murphy, P. Kennedy, P. Taylor, M. Rosas, S. Jones, J. McLaren, S. Deshpande, R. Andrews, , V. O'Donnell
This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.
bioRxiv · Aug 17, 2020Biochemistry