Author

R. Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Biochemistry· 1 Cell Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

P. Taylor· 3 shared V. Tyrrell· 3 shared A. N. Kapanidis· 2 shared D. White· 2 shared M. Aldrovandi· 2 shared P. Rodrigues· 2 shared S. A. Jones· 2 shared S. Deshpande· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

P. Taylor

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds

B. Fu, E. E. Brock, R. Andrews, J. C. Breiter, R. Tian, C. E. Toomey, J. Lachica, T. Lashley, M. Ryten, N. W. Wood, M. Vendruscolo, S. Gandhi, L. E. Weiss, J. S. Beckwith, S. F. Lee

RASP detects fluorescent puncta in complex cellular backgrounds with high precision and speed, outperforming existing methods by using image gradients to separate objects from noise.

bioRxiv · Dec 18, 2023Biophysics

Sex-specific Proximal Tubular Cell differentiation pathways identified by single-nucleus RNA

Y. A. Lu, T. Smith, S. Deshpande, C. T. Liao, B. Talabani, I. Grigorieva, A. Mason, R. Andrews, T. Bowen, P. Taylor, D. Fraser

This study identifies sex-specific differentiation pathways in proximal tubular cells using single-nucleus RNA sequencing in mice.

bioRxiv · Jun 2, 2023Cell Biology

Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements

D. Millrine, A. Cardus Figueras, J. Uceda Fernandez, R. Andrews, B. Szomolay, B. C. Cossins, C. Rice, J. Li, V. Tyrrell, L. mcLeod, P. Holmans, V. O'Donnell, P. Taylor, S. J. Turner, B. J. Jenkins, , S. A. Jones

The paper investigates how IFN-gamma-secreting CD4+ T-cells alter the transcriptional output of IL-6 by redirecting STAT1 and STAT3 to Alu-like retroelements during inflammation.

bioRxiv · Jul 18, 2022 · PreprintImmunology

Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

R. Andrews, H. Steuer, A. El-Sagheer, A. Mazumder, H. el Sayyed, A. Shivalingam, T. Brown, A. N. Kapanidis

The paper introduces Gap-Seq, a single-molecule imaging method that links DNA sequence to protein-DNA interaction kinetics by analyzing transient DNA binding to gapped substrates.

bioRxiv · Feb 27, 2022 · PreprintBiophysics

Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

M. Clement, K. Ladell, K. L. Miners, M. Marsden, L. Chapman, A. Cardus-Figueras, J. Scott, R. Andrews, S. Clare, V. V. Kriukova, K. R. Lupyr, O. V. Britanova, D. R. Withers, D. M. Chudakov, S. A. Jones, , I. Humphreys

The paper identifies IL-10-producing CD4+ T cells that develop via T-bet dependence and Arg1 coexpression, promoting cytomegalovirus persistence.

bioRxiv · Jan 25, 2022Immunology

High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organization

A. McMahon, R. Andrews, S. V. Ghani, T. Cordes, A. N. Kapanidis, N. C. Robb

This study uses super-resolution microscopy to analyze influenza virus pleomorphism, revealing stochastic assembly and RNP localization in long filaments.

bioRxiv · Sep 23, 2021Microbiology

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

M. Misheva, K. Kotzamanis, L. Davies, V. Tyrrell, P. Rodrigues, G. Benavides, H. Christine, R. Murphy, P. Kennedy, P. Taylor, M. Rosas, S. Jones, J. McLaren, S. Deshpande, R. Andrews, , V. O'Donnell

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

bioRxiv · Aug 17, 2020Biochemistry

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

bioRxiv · Oct 2, 2019Physiology