V. Tyrrell

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

Upregulated NF-κB pathway proteins may underlie APOE4 associated astrocyte phenotypes in sporadic Alzheimer's disease

This study identifies APOE44-associated astrocyte phenotypes in Alzheimer's disease, linking them to upregulated NF-κB pathway proteins.

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements

The paper investigates how IFN-gamma-secreting CD4+ T-cells alter the transcriptional output of IL-6 by redirecting STAT1 and STAT3 to Alu-like retroelements during inflammation.

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.