Evolutionary BiologybioRxivPreprint
Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelism
G. Mori, A. Liuzzi, L. Ronda…·R. Percudani
This study identifies a cysteine-rich urate oxidase in chickens that retains urate oxidation but can also regenerate urate, suggesting a repurposed role in reptilian skin and uricotelism.
DOI 10.1101/2023.06.02.543418