Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity
C. B. Lopez, L. J. Gonzalez Aparicio, Y. Yang, M. S. Hackbart
This study shows that copy-back viral genomes (cbVGs) induce cellular stress responses, including stress granules and translation inhibition, during RSV and parainfluenza virus infections, which reduce viral protein expression without affecting antiviral immunity.
bioRxiv · May 17, 2023Microbiology