Mutant strains of Escherichia coli lacking global regulators, arcA and fis, demonstrate better growth fitness by pathway reprogramming under acetate metabolism
S. Jindal, M. S. Iyer, P. Jyoti, S. K. Masakapalli, K. V. Venkatesh
This study shows that E. coli mutants lacking arcA and fis grow faster under acetate metabolism due to metabolic reprogramming, with increased TCA cycle flux and reduced gluconeogenesis.
bioRxiv · Jun 24, 2021 · PreprintMicrobiology