Enabling functionality and translation fidelity characterization of mRNA-based vaccines with a platform-based, antibody-free mass spectrometry detection approach
A. Q. Stiving, B. W. Roose, C. Tubbs, M. Haverick, A. Gruber, R. R. Rustandi, J. Kuiper, M. Schombs, H. Schuessler, X. Li
This paper develops an antibody-free mass spectrometry method to assess mRNA vaccine functionality and translation fidelity using cell-free translation and LC-MS.
bioRxiv · May 14, 2024 · PreprintBiochemistry