Author

R. R. Rustandi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

A. des Georges· 2 shared D. J. Weber· 2 shared E. Pozharski· 2 shared K. A. Adipietro· 2 shared K. M. Varney· 2 shared A. D. MacKerell· 1 shared A. Grishaev· 1 shared A. Krsitopeit· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

A. des Georges

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2 papers

Recent·Most cited

Membrane binding and pore formation is Ca2+-dependent for the Clostridioides difficile binary toxin

D. L. Abeyawardhane, S. E. Sevdalis, K. A. Adipietro, R. Godoy-Ruiz, K. M. Varney, I. F. Nawaz, A. X. Spittel, R. R. Rustandi, V. I. Silin, A. des Georges, E. Pozharski, D. J. Weber

This study shows that Ca2+ dissociation from CDTb's RBD1 triggers pore formation in endosomal membranes, differing from other binary toxins that rely on pH changes.

bioRxiv · Aug 18, 2023 · PreprintBiophysics

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

X. Xu, R. Ruiz, K. A. Adipietro, C. Peralta, D. Ben-Hail, K. M. Varney, M. E. Cook, B. M. Roth, P. T. Wilder, T. Cleveland, A. Grishaev, H. Neu, S. Michel, W. Yu, D. Beckett, , D. J. Weber

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.

bioRxiv · Nov 10, 2019 · PreprintBiophysics