Reprogramming the neuroblastoma epigenome with a mitochondrial uncoupler
H. Jiang, R. L. Greathouse, B. He, Y. Li, A. M. Li, B. Forgo, M. Yip, A. Li, M. Shih, S. Banuelos, M. Zhou, J. Gruber, H. Shimada, B. Chiu, J. Ye
This study uses a mitochondrial uncoupler to actively demethylate DNA in neuroblastoma cells, promoting differentiation and altering the epigenome.
bioRxiv · Sep 5, 2021 · PreprintCancer Biology