Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies
B. Pan, S. Gardner, K. Schultz, R. Perez, S. Deng, M. Shimogawa, K. Sato, E. Rhoades, R. Marmorstein, E. J. Petersson
This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.
bioRxiv · Apr 3, 2023Biochemistry