K. Sato

Virological characteristics of the SARS-CoV-2 KP.2 variant

This study investigates the virological properties of the SARS-CoV-2 KP.2 variant, finding it has higher viral fitness and immune resistance compared to JN.1, contributing to its rapid spread.

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement

This study determines the cryo-EM structures of two bispecific antibody types and shows that domain linkage rearrangement leads to activity enhancement by altering complex shape and dynamics.

Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

Mar1, an HMG-box protein, regulates n-alkane adsorption and cell morphology of the dimorphic yeast Yarrowia lipolytica

This study identifies MAR1, an HMG-box protein, as a regulator of n-alkane adsorption and cell morphology in Yarrowia lipolytica through transcriptional control of relevant genes.

A Protein Language Model for Exploring Viral Fitness Landscapes

This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.

Effect of Light and Water Agitation on Hatching Processes in Clown Anemonefish Amphiprion ocellaris

This study shows that darkness and water agitation regulate hatching enzyme secretion and chorion digestion in clown anemonefish, enabling synchronized hatching.

Virological characteristics of the SARS-CoV-2 JN.1 variant

This study investigates the virological properties of the SARS-CoV-2 JN.1 variant, focusing on its mutations and potential immune evasion capabilities.

Antiviral humoral immunity against SARS-CoV-2 Omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals

The paper assesses the humoral immune response to XBB.1.5 vaccine in infection-naive and XBB-infected individuals against various SARS-CoV-2 variants.

Virological characteristics of the SARS-CoV-2 Omicron HK.3 variant harboring the "FLip" substitution

This study investigates the virological properties of the SARS-CoV-2 HK.3 variant, a FLip variant with substitutions S:L455F and S:F456L, to assess its growth advantage.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

This study develops bispecific antibodies that restore effectiveness against SARS-CoV-2 variants resistant to existing antibodies by combining non-neutralizing antibodies targeting different epitopes.

Synaptic plasticity in the medial preoptic area of male mice encodes social experiences with female and regulates behavior toward young

This study identifies synaptic plasticity in the medial preoptic area of male mice as critical for shifting from aggressive to paternal behavior after mating and interaction with pups.

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

This study introduces AkaBLI, a method using Akaluc bioluminescence to track SARS-CoV-2 infection in vivo with higher sensitivity than NanoLuc, showing its utility in monitoring viral dynamics and vaccine efficacy.

Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity

This study examines virological parameters of SARS-CoV-2 variants correlating with spike protein fusogenicity, finding strong links with S1/S2 cleavage efficiency and plaque size.

Transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant

This study investigates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant, finding it to be highly immune evasive but with lower infectivity compared to other variants.

SARS-CoV-2 ORF7a mutation found in BF.5 and BF.7 sublineages impacts its functions

The paper evaluates the effect of the H47Y mutation in ORF7a of SARS-CoV-2 BF.5 and BF.7 sublineages on its three main functions, finding it impairs IFN-I antagonism and MHC-I downregulation but not anti-SERINC5 function.

Sensitivity of BA.2.86 to prevailing neutralising antibody responses

This study assesses BA.2.86's sensitivity to neutralising antibodies using monoclonal antibodies and serum samples from Stockholm.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against Omicron subvariants including EG.5

This study evaluates the antiviral efficacy of XBB breakthrough infection sera against EG.5.1 and other Omicron subvariants, finding comparable neutralization titers and suggesting immune evasion is not the main driver of EG.5.1's spread.

Direct photoreception of a pituitary endocrine cell, melanotroph, induces a hormone release

The paper shows that melanotrophs in the pituitary directly sense short-wavelength light, triggering hormone release and UV protection through Opn5m.

YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution

The paper identifies YAP-driven reprogramming of oral epithelial stem cells into tumor-initiating cells using single-cell multiomics, revealing conserved transcriptional programs linked to poor patient survival.

Propagation path of a flowering cherry (Cerasus x yedoensis) cultivar 'Somei-Yoshino' traced by somatic mutations

The paper traces the propagation path of the Somei-Yoshino cherry cultivar by identifying somatic mutations across 46 clones and clustering them into genetic groups.

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.16 variant

This study characterizes the virological features of the SARS-CoV-2 Omicron XBB.1.16 variant, showing increased transmissibility and immune evasion compared to previous variants.

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

Determination of the factors responsible for host tropism of SARS-CoV-2-related bat coronaviruses

The paper identifies specific residues in the spike protein and ACE2 receptor that determine the host tropism of two SARS-CoV-2-related bat coronaviruses.

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

Structure of the human Bre1 complex bound to the nucleosome

The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.

Wandering albatrosses exert high take-off effort only when both wind and waves are gentle

This study estimates wind and wave conditions experienced by wandering albatrosses using animal-borne sensors and finds that take-off effort is highest when both wind and waves are gentle.