Author

S. Gardner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:cryo-EM· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

D. Bubeck· 3 shared A. Chandrashekar· 1 shared A. Chang· 1 shared A. Cook· 1 shared A. Menny· 1 shared A. P. Joseph· 1 shared A. Van Ry· 1 shared B. P. Morgan· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

D. Bubeck

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of substrate progression through the chaperonin cycle

S. Gardner, M. C. Darrow, N. Lukoyanova, K. Thalassinos, H. R. Saibil

The paper uses cryoEM to determine structures of GroEL-GroES complexes with Rubisco, revealing conformational changes and interactions during the chaperonin cycle.

bioRxiv · May 29, 2023 · PreprintBiophysics

Semi-synthetic CoA-alpha-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies

B. Pan, S. Gardner, K. Schultz, R. Perez, S. Deng, M. Shimogawa, K. Sato, E. Rhoades, R. Marmorstein, E. J. Petersson

This study creates a semi-synthetic inhibitor of NatB using coenzyme A and full-length alpha-synuclein, revealing structural and conformational changes upon binding.

bioRxiv · Apr 3, 2023Biochemistry

Structural basis for membrane attack complex inhibition by CD59

E. C. Couves, S. Gardner, T. B. Voisin, J. K. Bickel, P. J. Stansfeld, E. W. Tate, D. Bubeck

This study reveals how CD59 inhibits MAC pore formation by binding C8 and deflecting C9, using cryo-EM structures and simulations.

bioRxiv · Sep 5, 2022Immunology

Structural insights into the assembly and activation of IL-27 signalling complex

Y. Jin, P. K. Fyfe, S. Gardner, S. Wilmes, D. Bubeck, I. Moraga

This study determines the structure of the IL-27 receptor recognition complex using cryoEM, revealing how IL-27 bridges IL-27R and GP130 to initiate signaling.

bioRxiv · Feb 18, 2022 · PreprintImmunology

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

J. Yu, N. Collins, N. B. Mercado, K. McMahan, A. Chandrashekar, J. Liu, T. Anioke, A. Chang, V. Giffin, D. Hope, D. Sellers, F. Nampanya, S. Gardner, J. Barrett, H. Wan, , D. H. Barouch

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

bioRxiv · Sep 13, 2021Microbiology

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

A. Menny, M. Serna, C. M. Boyd, S. Gardner, A. P. Joseph, B. P. Morgan, M. Topf, N. J. Brooks, D. Bubeck

This study uses cryo-EM to show how the complement membrane attack complex interacts with lipid bilayers through distinct mechanisms involving C6/C7 and C8/C9, revealing structural insights into pore formation and membrane disruption.

bioRxiv · Aug 17, 2018Biophysics