Author

M. Shirts

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. J. Friedman· 1 shared A. Sarkar· 1 shared E. T. Liechty· 1 shared J. Fox· 1 shared L. D. Kramer· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiochemistry

A. J. Friedman

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1 paper

Recent·Most cited

Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid

A. J. Friedman, E. T. Liechty, L. D. Kramer, A. Sarkar, J. Fox, M. Shirts

This study identifies amorphadiene as a selective allosteric inhibitor of PTP1B, showing it binds to multiple sites on the C-terminus and stabilizes the PTP1B-AD complex.

bioRxiv · May 18, 2022Biochemistry