Streamlined DNA template preparation and co-transcriptional 5' capped RNA synthesis enabled by solid-phase catalysis
G. G. Marquina, A. Zhang, M. Sproviero, Y. Fang, A. F. Gardner, G. B. Robb, S. H. Chan, M.-Q. Xu
This paper demonstrates a solid-phase enzymatic platform for streamlined mRNA synthesis, enabling efficient and continuous production of capped RNA without purification steps.
bioRxiv · Oct 28, 2023 · PreprintBiochemistry