S. H. Chan

MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

Co-transcriptional capping using an RNA capping enzyme-T7 RNA polymerase fusion protein

This paper describes an RNA capping enzyme-T7 RNA polymerase fusion protein that efficiently generates capped synthetic mRNA in a one-step process, achieving up to 95% Cap-1 incorporation.

Streamlined DNA template preparation and co-transcriptional 5' capped RNA synthesis enabled by solid-phase catalysis

This paper demonstrates a solid-phase enzymatic platform for streamlined mRNA synthesis, enabling efficient and continuous production of capped RNA without purification steps.

Biochemical characterization of mRNA capping enzyme from Faustovirus

This study characterizes a single-subunit RNA capping enzyme from Faustovirus, showing it efficiently generates Cap-0 structures and has advantageous properties for synthetic mRNA manufacturing.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

Coupling of protein condensates to ordered lipid domains determines functional membrane organization

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

MCART1 is required for mitochondrial NAD transport

The paper identifies MCART1 as a mitochondrial NAD+ transporter in human cells by showing its essentiality with ETC components and its effect on NAD levels and mitochondrial function.

Dihydroxyacetone phosphate signals glucose availability to mTORC1

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.