A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar
J. A. Watson, T. Lamb, J. Holmes, D. Warrell, K. T. Thwin, Z. L. Aung, M. T. Nwe, F. Smithuis, E. A. Ashley
This paper proposes a Bayesian adaptive design for antivenom dose-finding trials, showing it can identify optimal doses with fewer patients than traditional methods.
bioRxiv · Feb 6, 2020Pharmacology & Toxicology