Author

J. A. Watson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:clinical cohort / trial· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

G. Deak· 2 shared H. Burdett· 2 shared H. Wapenaar· 2 shared M. D. Wilson· 2 shared M. R. Taylor· 2 shared N. J. White· 2 shared A. Das· 1 shared A. G. Cook· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

G. Deak

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Author profile →

6 papers

Recent·Most cited

Transmission-blocking activity of artesunate, chloroquine and methylene blue on Plasmodium vivax gametocytes.

V. Chaumeau, P. Wasisakun, J. A. Watson, T. Oo, S. Aryalamloed, M. P. Sue, G. N. Htoo, N. M. Tha, L. Archusuksan, S. Sawasdichai, G. Gornsawun, S. Mehra, N. J. White, F. Nosten

This study evaluates the transmission-blocking effects of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes, finding that only artesunate and methylene blue significantly reduce oocyst and sporozoite development.

bioRxiv · Feb 18, 2024 · PreprintMicrobiology

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.

H. Wapenaar, G. Clifford, W. Rolls, H. Burdett, Y. Zhang, G. Deak, J. Zou, M. R. Taylor, J. Mills, J. A. Watson, D. Kumar, A. Das, D. Valsakumar, J. Bramham, P. Voigt, M. D. Wilson

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

bioRxiv · Oct 29, 2023Biochemistry

Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

G. Deak, H. Wapenaar, G. Sandoval, R. Chen, M. R. Taylor, H. Burdett, J. A. Watson, M. W. Tuijtel, S. Webb, M. D. Wilson

This study characterizes the structure of nucleosome core particles from Trypanosoma brucei, revealing unique histone alterations that affect DNA and protein interactions.

bioRxiv · Apr 17, 2023Biochemistry

Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome

J. A. Watson, R. Pantier, U. Jayachandran, K. Chhatbar, B. Alexander-Howden, V. Kruusvee, M. Prendecki, A. P. Bird, A. G. Cook

This study presents the crystal structure of SALL4 zinc fingers bound to AT-rich DNA, showing flexible recognition and links to Okihiro syndrome mutations.

bioRxiv · Jun 14, 2022Biochemistry

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar

J. A. Watson, T. Lamb, J. Holmes, D. Warrell, K. T. Thwin, Z. L. Aung, M. T. Nwe, F. Smithuis, E. A. Ashley

This paper proposes a Bayesian adaptive design for antivenom dose-finding trials, showing it can identify optimal doses with fewer patients than traditional methods.

bioRxiv · Feb 6, 2020Pharmacology & Toxicology

A pharmacokinetic-pharmacodynamic assessment of the hepatic and bone-marrow toxicities of the new trypanoside fexinidazole

J. A. Watson, N. Strub-Wourgraft, A. Tarral, I. Ribeiro, J. Tarning, N. J. White

This study assesses the toxicity of fexinidazole in Chagas and g-HAT patients, finding dose-dependent neutropenia, thrombocytopenia, and hepatotoxicity in Chagas but not g-HAT.

bioRxiv · Dec 4, 2018Pharmacology & Toxicology