Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice
C. B. Herber, W. C. Krause, L. Wang, J. R. Bayrer, A. Li, M. T. Schmitz, A. Fields, B. Ford, M. S. Reid, D. K. Nomura, R. A. Nissenson, S. M. Correa, H. A. Ingraham
This study identifies estrogen signaling in arcuate Kiss1 neurons as a key regulator of sex-dependent bone density in female mice, revealing a novel neuroskeletal pathway.
bioRxiv · May 21, 2018Physiology