Author

M. Todisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. W. Szostak· 3 shared A. Radakovic· 2 shared A. Bannan· 1 shared A. Lewicka· 1 shared D. Ding· 1 shared H. R. M. Aitken· 1 shared J. A. Piccirilli· 1 shared J. Szostak· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

J. W. Szostak

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4 papers

Recent·Most cited

RNA complexes with nicks and gaps: thermodynamic and kinetic effects of coaxial stacking and dangling ends

M. Todisco, A. Radakovic, J. Szostak

This paper investigates the thermodynamic and kinetic effects of coaxial stacking and dangling ends on RNA complex stability and binding kinetics.

bioRxiv · Apr 13, 2024Biophysics

Structure-guided aminoacylation and assembly of chimeric RNAs

A. Radakovic, A. Lewicka, M. Todisco, H. R. M. Aitken, Z. Weiss, S. Kim, A. Bannan, J. A. Piccirilli, J. W. Szostak

The paper shows that specific RNA sequences can be nonenzymatically aminoacylated and ligated to form amino acid-bridged stem-loop RNAs, with structural and functional similarities to modern tRNA.

bioRxiv · Mar 2, 2024 · PreprintBiochemistry

Transient states during the annealing of mismatched and bulged oligonucleotides

M. Todisco, D. Ding, J. W. Szostak

This study examines how mismatches and bulges in DNA/RNA duplexes affect hybridization kinetics and shows that transient low-specificity states can support prebiotic copying reactions.

bioRxiv · Sep 27, 2023Biochemistry

Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides

M. Todisco, J. W. Szostak

This study calculates kinetic parameters for RNA oligonucleotide interactions and shows they can create kinetic traps that slow hybridization timescales, potentially aiding RNA replication in early life.

bioRxiv · Jun 9, 2022Biochemistry