Author

J. A. Piccirilli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bannan· 1 shared A. Lewicka· 1 shared A. Radakovic· 1 shared D. C. Wallace· 1 shared D. Liu· 1 shared E. Seifert· 1 shared F. A. Thelot· 1 shared H. Gamper· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. Bannan

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Author profile →

3 papers

Recent·Most cited

Structure-guided aminoacylation and assembly of chimeric RNAs

A. Radakovic, A. Lewicka, M. Todisco, H. R. M. Aitken, Z. Weiss, S. Kim, A. Bannan, J. A. Piccirilli, J. W. Szostak

The paper shows that specific RNA sequences can be nonenzymatically aminoacylated and ligated to form amino acid-bridged stem-loop RNAs, with structural and functional similarities to modern tRNA.

bioRxiv · Mar 2, 2024 · PreprintBiochemistry

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology

S. Maharjan, H. Gamper, Y. Yamaki, R. Y. Henley, N. Sheng, T. Suzuki, T. Suzuki, J. A. Piccirilli, M. Wanunu, E. Seifert, D. C. Wallace, Y.-M. Hou

The paper shows that N1-methylation at position 9 of mt-Leu(UAA) stabilizes wild-type mt-tRNA but destabilizes pathogenic variants, suggesting methylation control could be therapeutic.

bioRxiv · Dec 9, 2023Cell Biology

Sub-3 Angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly

D. Liu, F. A. Thelot, J. A. Piccirilli, M. Liao, P. Yin

This paper introduces a method to improve cryo-EM analysis of RNA structures by engineering kissing-loop sequences for homomeric assembly, achieving high-resolution reconstructions of RNA molecules.

bioRxiv · Aug 11, 2021Biophysics