Author

M. Tokano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

M. Kawano· 2 shared R. Takagi· 2 shared S. Matsushita· 2 shared T. Yamamoto· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersImmunology

M. Kawano

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2 papers

Recent·Most cited

Istradefylline, an adenosine A2a receptor antagonist, ameliorates neutrophilic airway inflammation and psoriasis in mice

M. Tokano, M. Kawano, R. Takagi, S. Matsushita

This study shows that istradefylline and related inhibitors reduce IL-17A production in mouse models of neutrophilic inflammation and psoriasis.

bioRxiv · May 21, 2021Immunology

Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor to promote neutrophilic inflammation

M. Tokano, S. Matsushita, R. Takagi, T. Yamamoto, M. Kawano

This study shows adenosine enhances IL-17A secretion by Th17 cells via A2aR, promoting neutrophilic inflammation and suggesting A2aR antagonists as potential treatments for Th17-related autoimmune diseases.

bioRxiv · Apr 29, 2021Immunology