T. Yamamoto

Role of the medial agranular cortex in unilateral spatial neglect

This study investigates how different regions of the rodent medial agranular cortex affect unilateral spatial neglect severity and recovery.

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

This study investigates how molecular chirality leads to cellular chirality in epithelial cells, revealing that concentric actomyosin filaments drive intracellular rotation.

Neutralizing antibody responses and cellular responses against severe acute respiratory syndrome coronavirus 2 omicron subvariant BA.5 after an mRNA severe acute respiratory syndrome coronavirus 2 vaccine dose in kidney transplant recipients

This study evaluates antibody and cellular immune responses in kidney transplant recipients after three mRNA vaccine doses, finding lower neutralizing titers and T cell responses compared to healthy controls.

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

Shell protein composition specified by NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles

The paper identifies how NEAT1 domains specify shell protein composition in paraspeckles, enabling their independence from nuclear speckles through phase separation.

Mechanism Underlying the Immune Responses of a Sublingual Vaccine for SARS-CoV-2 with RBD Antigen and Adjuvant, Poly(I:C) or AddaS03, in Non-human Primates

This study evaluates the safety and immune response of a sublingual SARS-CoV-2 vaccine with RBD antigen and Poly(I:C) or AddaS03 adjuvant in non-human primates, finding Poly(I:C) induces a balanced immune response.

Orchid seed germination through auto-activation of mycorrhizal symbiosis signaling regulated by gibberellin

This study investigates how gibberellin (GA) affects Bletilla striata seed germination and mycorrhizal symbiosis, revealing that GA inactivation enables auto-activation of the symbiosis pathway.

Polymer brush inspired by ribosomal RNA transcription

The paper develops a scaling theory for polymer brushes inspired by ribosomal RNA transcription, showing how polymerization rate affects monomer diffusion and volume fraction.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast

The paper develops a theory explaining how tandemly repeated genes in fission yeast contribute to heterochromatin assembly through small RNA production and histone methylation.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Frame Editors for Precise, Template-Free Frameshifting

This paper introduces Frame Editors (FEs) that improve CRISPR-Cas9 editing accuracy by inducing controlled frameshifts without templates, reducing random mutations and off-target effects.

Elasticity control of entangled chromosomes: crosstalk between condensin complexes and nucleosomes

The paper constructs a theoretical model to explain the formation of a unique bean-shaped structure formed by mutant condensin complexes and nucleosomes in Xenopus egg extracts.

Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumor

A low carbohydrate diet suppresses neuroendocrine tumor onset and progression by reducing insulin signaling and PI3K-Akt-mTOR pathway activity in mouse models and correlates with better prognosis in patients.

SARS-CoV-2 Sublingual Vaccine with RBD Antigen and Poly(I:C) Adjuvant: Preclinical Study in Cynomolgus Macaques

This study evaluates a sublingual SARS-CoV-2 vaccine with RBD antigen and poly(I:C) adjuvant in cynomolgus macaques, showing mucosal and systemic immune responses without allergic reactions.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Hydrodynamics shapes self-recruitment in anemonefishes

The paper compares self-recruitment and larval dispersal between a semi-enclosed bay and an open coast, finding that stronger cross-shore currents in the bay reduce local retention and self-recruitment.

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

Application of B cell immortalization for the isolation of antibodies and B cell clones from vaccine and infection settings

This study applies Bcl-6/Bcl-xL retroviral transduction to isolate antibodies and generate B cell clones from various B cell populations in healthy and infected individuals.

Loop extrusion driven volume phase transition of entangled chromosomes

The paper develops a theory explaining how loop extrusion by condensin drives a volume phase transition in entangled chromosomes, leading to their collapse.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

The establishment of multiple knockout mutants of Colletotrichum orbiculare by CRISPR/Cas9 and Cre/loxP systems

This paper develops CRISPR/Cas9 and Cre/loxP systems to efficiently generate multiple knockout mutants in Colletotrichum orbiculare and identifies functional sugar transporters.

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

This study shows naked mole-rats (NMRs) resist chemical carcinogenesis through reduced inflammatory responses linked to necroptosis deficiency.

Antibacterial 3D-printed PMMA/ceramic composites

This paper investigates 3D-printed PMMA/ceramic composites with antibacterial properties, finding that aluminum nitride provides the best dispersion and antibacterial effect against E. coli.

Lateral surface pressure generated by nascent ribosomal RNA suppresses growth of fibrillar centers in the nucleolus

The paper develops a theoretical model explaining how nascent pre-rRNAs suppress fibrillar center growth in nucleoli through lateral pressure, supported by experimental validation.

Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks

The paper uses graph neural networks to infer cell coordination rules from live tissue data, revealing region-specific coordination patterns in mammalian epidermis.

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor to promote neutrophilic inflammation

This study shows adenosine enhances IL-17A secretion by Th17 cells via A2aR, promoting neutrophilic inflammation and suggesting A2aR antagonists as potential treatments for Th17-related autoimmune diseases.