Optimized detection of allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in cancer
F. Perez-Villatoro, J. Oikkonen, J. Casado, A. Chernenko, D. C. Gulhan, M. Tumiati, Y. Li, K. Lavikka, S. Hietanen, J. Hynninen, U.-M. Haltia, J. S. Tyrmi, H. Laivuori, P. Konstantinopoulos, S. Hautaniemi, , A. Farkkila
The paper develops a tumor-specific method to detect allelic imbalances for HRD prediction, showing improved clinical outcome prediction in ovarian and breast cancers.
bioRxiv · Aug 19, 2021Cancer Biology