The paper investigates L1 retrotransposition in HGSC, finding that despite high L1 mRNA expression, only a third of tumors show somatic insertions, with variability in retrotransposition frequency and patterns.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Tracing back primed resistance in cancer via sister cells

J. Dai, S. Zheng, M. M. Falco, J. Bao, J. Eriksson, S. Pikkusaari, S. Forsten, J. Jiang, W. Wang, L. Gao, F. Perez-Villatoro, O. Dufva, K. Saeed, Y. Wang, A. Amiryousefi, , A. Vähärautio

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

bioRxiv · Jul 6, 2022Cancer Biology

Optimized detection of allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in cancer

F. Perez-Villatoro, J. Oikkonen, J. Casado, A. Chernenko, D. C. Gulhan, M. Tumiati, Y. Li, K. Lavikka, S. Hietanen, J. Hynninen, U.-M. Haltia, J. S. Tyrmi, H. Laivuori, P. Konstantinopoulos, S. Hautaniemi, , A. Farkkila

The paper develops a tumor-specific method to detect allelic imbalances for HRD prediction, showing improved clinical outcome prediction in ovarian and breast cancers.

bioRxiv · Aug 19, 2021Cancer Biology

Epigenetic inhibitors sensitize DLBCL cells to rituximab and doxorubicin

C. Facciotto, J. Casado, L. Turunen, S.-K. Leivonen, M. Tumiati, V. Rantanen, L. Kauppi, R. Lehtonen, S. Leppä, K. Wennerberg, S. Hautaniemi

This study identifies epigenetic inhibitors that enhance the effectiveness of immunochemotherapy in DLBCL by disrupting DNA repair and cell cycle pathways.

bioRxiv · Feb 6, 2019 · PreprintCancer Biology