Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail
M. V. Fernandez, H. K. Hoffman, N. Pezeshkian, P. R. Tedbury, S. B. van Engelenburg, E. O. Freed
This study investigates why MT-4 T-cells allow HIV-1 replication despite lacking the gp41 cytoplasmic tail, finding faster viral production, higher surface Env, and increased cell-to-cell transmission contribute to this permissivity.
Journal of Virology · Nov 9, 2020Peer-reviewedMicrobiology