P. R. Tedbury

Mpox Virus is Inhibited By Nucleoside Analogues Including the Acyclic Phosphonates Tenofovir and Adefovir

The paper tests nucleoside analogues for antiviral activity against orthopoxviruses, finding tenofovir and adefovir effective with low toxicity.

HIV-1 resistance to islatravir/tenofovir combination therapy in wild-type or NRTI resistant strains of diverse HIV-1 subtypes

This study evaluates resistance to islatravir and tenofovir in HIV-1 strains with mutations K65R, M184V, and S68G/N, showing that their combination has a high genetic barrier to resistance.

Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies

This study identifies E166V as a key mutation conferring high nirmatrelvir resistance in SARS-CoV-2, with differential effects on Omicron and WA1 variants, and explores strategies to overcome resistance.

Subgenomic SARS-CoV-2 replicon and reporter replicon cell lines enable ultrahigh throughput antiviral screening and mechanistic studies with antivirals, viral mutations or host factors that affect COVID-19 replication

This paper develops SARS-CoV-2 replicon systems and cell lines for antiviral screening and mechanistic studies, enabling research at lower biosafety levels.

Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail

This study investigates why MT-4 T-cells allow HIV-1 replication despite lacking the gp41 cytoplasmic tail, finding faster viral production, higher surface Env, and increased cell-to-cell transmission contribute to this permissivity.

Development of Resistance to 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA) by Wild-Type and Nucleoside Reverse Transcriptase Inhibitor Resistant Human Immunodeficiency Virus Type 1

This study identifies mutations conferring resistance to EFdA in HIV-1, showing M184V as the primary determinant and A114S enhancing resistance.