The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
G. Khelashvili, E. Kots, X. Cheng, M. V. Levine, H. Weinstein
The paper uses molecular dynamics simulations to reveal an allosteric mechanism in TMEM16F that opens a lipid-conductive groove, enabling scramblase activity.
bioRxiv · May 23, 2022Biophysics