BiophysicsbioRxiv
The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor
M. V. LeVine, D. S. Terry, G. Khelashvili…·H. Weinstein
The paper identifies an allosteric mechanism involving residues F259 and I359 that modulates Na+ release and substrate transport in SLC6 family proteins.
DOI 10.1073/pnas.1903020116