Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels
N. Conceicao-Neto, W. Pierson, M. Vacca, M. Beyens, B. De Clerck, L. Aerts, B. Voeten, D. De Pooter, L. Verschueren, K. Dockx, M. Vandenberk, E. De Troyer, K. Verwilt, C. Van Hove, M. Verslegers, , E. Van Gulck
This study shows that sustained HBsAg loss and immune cell expansion in the liver occur after therapeutic DNA vaccination in a mouse model when HBsAg levels are low.
bioRxiv · Sep 4, 2023Immunology