M. Vacca

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels

This study shows that sustained HBsAg loss and immune cell expansion in the liver occur after therapeutic DNA vaccination in a mouse model when HBsAg levels are low.

HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer

This study identifies HAPLN1 as a driver of peritoneal metastasis in pancreatic cancer by enhancing tumor cell plasticity and immunomodulation.

Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia

The paper shows that early neutrophilia driven by aerobic glycolysis supports host metabolism and delays cancer cachexia in murine models.

Semaphorin 3C exacerbates liver fibrosis

This study identifies SEMA3C as a key driver of liver fibrosis by enhancing TGF-β signaling in hepatic stellate cells.

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

This study identifies MSR1 as a key mediator of lipid-induced inflammation in NAFLD, showing its role in macrophage activation and potential as a therapeutic target.