N. Conceicao-Neto

Patient phenotypes and their relation to TNFα signaling and immune cell composition in critical illness and autoimmune disease

The paper identifies a hyper-inflammatory phenotype linked to TNF signaling and mature neutrophils in critical illness and autoimmune disease using machine learning and patient data.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

Sustained liver HBsAg loss and clonal T and B cell expansion upon therapeutic DNA vaccination require low HBsAg levels

This study shows that sustained HBsAg loss and immune cell expansion in the liver occur after therapeutic DNA vaccination in a mouse model when HBsAg levels are low.

AAV-HBV mouse model replicates immune exhaustion patterns of chronic HBV patients at single-cell level

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

The paper develops a workflow for collecting and analyzing liver immune cells via fine-needle aspirates and single-cell RNA sequencing to better understand tissue-specific immunity in chronic hepatitis B.

Hymenoptera associated eukaryotic virome lacks host specificity

The study identifies a diverse virome in honey bees and finds that many viruses are shared across Hymenoptera species, suggesting a lack of host specificity.

A robust human norovirus replication model in zebrafish larvae

This study establishes a zebrafish larval model for human norovirus replication, showing high viral titers and antiviral response potential.