PCNA activates the MutLγ endonuclease to promote meiotic crossing over
N. Hunter, D. S. Kulkarni, S. Owens, M. Honda, M. Ito, Y. Yang, M. W. Corrigan, L. Chen, A. L. Quan
This paper shows PCNA activates the MutLγ endonuclease to promote meiotic crossing over by facilitating strand-specific cleavage of Holliday junctions.
bioRxiv · Feb 12, 2020Biochemistry