M. Honda

A double-ring of human RAD52 remodels replication forks restricting fork reversal

The paper shows human RAD52 forms a double-ring structure around stalled replication forks, remodeling them via DNA strand exchange to prevent reversal by SMARCAL1.

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

Human hnRNPA1 reorganizes telomere-bound Replication Protein A

The paper shows hnRNPA1 remodels RPA bound to telomeric ssDNA, forming a ternary complex regulated by TERRA.

Single-molecule analysis of the improved variants of the G-quadruplex recognition protein G4P

The paper analyzes the binding kinetics and selectivity of G4P and its variants using single-molecule techniques, finding that increasing RSM units enhances affinity for telomeric G4s.

RAD52 prevents accumulation of Polα-dependent replication gaps at perturbed replication forks

This study shows RAD52 prevents Polα-dependent replication gaps by enabling RAD51/Pol repriming at reversed replication forks, which limits DNA damage and improves cell viability during replication stress.

PCNA activates the MutLγ endonuclease to promote meiotic crossing over

This paper shows PCNA activates the MutLγ endonuclease to promote meiotic crossing over by facilitating strand-specific cleavage of Holliday junctions.