Zebrafish Drug Screening Identifies Erlotinib as an Inhibitor of Wnt/β-Catenin Signaling and Self-Renewal in T-cell Acute Lymphoblastic Leukemia
M. A. Al-Hamaly, A. H. Cox, M. G. Haney, W. Zhang, E. C. Arvin, S. Sampathi, M. Wimsett, J. S. Blackburn
This study identifies Erlotinib as a Wnt/β-catenin inhibitor effective in zebrafish and human cells, reducing leukemia-initiating cell self-renewal and disease progression.
bioRxiv · Aug 28, 2023Cancer Biology