Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
M. Woody, M. Capitanio, D. Winkelmann, E. M. Ostap, Y. E. Goldman
This study uses ultra-high-speed optical traps to observe rapid mechanical events in cardiac myosin, showing the working stroke occurs before phosphate release and is influenced by force.
bioRxiv · Jun 27, 2019Biochemistry