E. M. Ostap

Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks

This study shows myosin-I enhances the force generation of Arp2/3 complex-nucleated actin networks by thinning them and promoting symmetry breaking.

Endocytic myosin-1 is a force-insensitive, power-generating motor

The paper measures the force-sensitivity of yeast endocytic myosin Myo5 and finds it generates power rather than acting as a force-sensitive anchor during endocytosis.

KIF1A is kinetically tuned to be a super-engaging motor under hindering loads

This study uses optical tweezers to show KIF1A generates higher force and sustains longer attachment under hindering loads compared to KIF5B, with rapid microtubule reengagement.

Kinesin-4 Motor Teams Effectively Navigate Dendritic Microtubule Arrays Through Track Switching and Regulation of Microtubule Dynamics

This study shows KIF21B kinesin-4 motors navigate mixed polarity microtubules in dendrites through directional switching and microtubule dynamics regulation.

Cega: A Single Particle Segmentation Algorithm to Identify Moving Particles in a Noisy System

The paper introduces Cega, a single particle segmentation algorithm that improves particle tracking in noisy systems by using KL divergence to distinguish moving particles from background noise.

Human hypertrophic cardiomyopathy mutation R712L suppresses the working stroke of cardiac myosin and can be rescued by omecamtiv mecarbil

This study shows that the HCM mutation R712L in β-cardiac myosin reduces the working stroke, which is reversed by the drug omecamtiv mecarbil.

Strain-Dependent Kinetic Properties of KIF3A and KIF3C Tune the Mechanochemistry of the KIF3AC Heterodimer

This study investigates the kinetic properties of KIF3A and KIF3C in KIF3AC heterodimers, showing strain-dependent mechanochemistry and force sensitivity.

Modulation of kinesin’s load-bearing capacity by force geometry and the microtubule track

This study shows that kinesin's attachment duration to microtubules varies significantly based on force geometry, with parallel forces increasing attachment time up to 10-fold compared to vertical forces.

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

This study uses ultra-high-speed optical traps to observe rapid mechanical events in cardiac myosin, showing the working stroke occurs before phosphate release and is influenced by force.

Positive Cardiac Inotrope, Omecamtiv Mecarbil, Activates Muscle Despite Suppressing the Myosin Working Stroke

This study shows that omecamtiv mecarbil increases cardiac output by inhibiting myosin working stroke and enhancing thin filament activation through cooperative mechanisms.