Cytoplasmic domain and enzymatic activity of ACE2 is not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells
H. Yang, x. Zhao, M. xun, L. Xu, B. Liu, H. Wang
This study shows SARS-CoV-2 entry into host cells relies on clathrin-mediated endocytosis and phosphoinositides, with ACE2's cytoplasmic domain and enzymatic activity not required for this process.
bioRxiv · Mar 1, 2021Microbiology