Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
M. Akatsuka, Y. Masuda, H. Tatsumi, M. Yamakage
This study shows that rhTM and its D1 domain reduce extracellular histone H3 levels and improve kidney injury and survival in sepsis-induced rats.
bioRxiv · Dec 9, 2019Pharmacology & Toxicology