Structure Determination of Inactive-State GPCRs with a Universal Nanobody
M. J. Robertson, M. M. Papasergi-Scott, F. He, A. B. Seven, J. G. Meyerowitz, O. Panova, M.-C. Peroto, T. Che, G. Skiniotis
This paper uses nanobodies to determine cryo-EM structures of inactive-state GPCRs, achieving resolutions comparable to X-ray crystallography and providing insights into ligand binding.
bioRxiv · Nov 2, 2021Biophysics