Author

A. B. Seven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

G. Skiniotis· 4 shared O. Panova· 3 shared B. K. Kobilka· 2 shared F. He· 2 shared G. Eskici· 2 shared M. J. Robertson· 2 shared M. M. Papasergi-Scott· 2 shared T. Che· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersBiophysics

G. Skiniotis

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4 papers

Recent·Most cited

Time-resolved cryo-EM of G protein activation by a GPCR

M. M. Papasergi-Scott, G. Perez-Hernandez, H. Batebi, Y. Gao, G. Eskici, A. B. Seven, O. Panova, D. Hilger, M. Casiraghi, F. He, L. Maul, P. Gmeiner, B. K. Kobilka, P. W. Hildebrand, G. Skiniotis

This study uses time-resolved cryo-EM to visualize the conformational changes in a GPCR-G protein complex during activation, revealing the structural pathway of G protein dissociation.

bioRxiv · Mar 20, 2023Pharmacology & Toxicology

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

Q. Qu, W. Huang, D. Aydin, J. M. Paggi, A. B. Seven, H. Wang, S. Chakraborty, T. Che, J. F. DiBerto, M. J. Robertson, A. Inoue, B. L. Roth, S. Majumdar, R. O. Dror, B. K. Kobilka, G. Skiniotis

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

bioRxiv · Dec 7, 2021 · PreprintBiophysics

Structure Determination of Inactive-State GPCRs with a Universal Nanobody

M. J. Robertson, M. M. Papasergi-Scott, F. He, A. B. Seven, J. G. Meyerowitz, O. Panova, M.-C. Peroto, T. Che, G. Skiniotis

This paper uses nanobodies to determine cryo-EM structures of inactive-state GPCRs, achieving resolutions comparable to X-ray crystallography and providing insights into ligand binding.

bioRxiv · Nov 2, 2021Biophysics

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6

Y. Gao, G. Eskici, S. Ramachandran, F. Poitevin, A. B. Seven, O. Panova, G. Skiniotis, R. A. Cerione

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.

bioRxiv · Apr 1, 2020Biophysics