M. J. Robertson

Metric Ion Classification (MIC): A deep learning tool for assigning ions and waters in cryo-EM and x-ray crystallography structures

The paper introduces a deep learning tool called Metric Ion Classification (MIC) to classify ions and waters in cryo-EM and x-ray crystallography structures, identifying mismodeled ions in the PDB.

Downregulation of Let-7 miRNA promotes Tc17 differentiation and emphysema via de-repression of RORγt

This study shows that downregulation of let-7 miRNA promotes Tc17 differentiation and emphysema by de-repressing RORγt in mice.

Parallel genomic basis of age at maturity across spatial scales in Atlantic Salmon

This study investigates the genomic basis of age at maturity in North American Atlantic Salmon, finding both parallel and population-specific genetic patterns.

Modulation of cannabinoid receptor signaling by endocannabinoids

This study investigates how endocannabinoids modulate CB1 receptor signaling by comparing their activation of Gi1 with synthetic cannabinoids and revealing structural differences in ligand binding.

Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins

The paper develops and validates OPLS-AA/M force field parameters for simulating GPCRs and other membrane proteins, showing reliable behavior compared to quantum mechanics and experimental data.

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

Plasticity in Ligand Recognition at Somatostatin Receptors

The paper presents cryo-EM structures of SSTR2 with ligands and Gi protein, revealing ligand recognition mechanisms and subtype selectivity.

Structure Determination of Inactive-State GPCRs with a Universal Nanobody

This paper uses nanobodies to determine cryo-EM structures of inactive-state GPCRs, achieving resolutions comparable to X-ray crystallography and providing insights into ligand binding.

Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.

The paper compares RSV infection in HEp-2 and A549 cells using four strains, finding subgroup-dependent gene expression differences and A549's greater antiviral response.

GemSpot: A Pipeline for Robust Modeling of Ligands into CryoEM Maps

GemSpot models ligand poses into cryoEM maps using computational chemistry methods, achieving accurate interactions and map agreement in validated cases.