Author

M.-P. Valignat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

O. Theodoly· 4 shared L. Aoun· 3 shared M. Biarnes-Pelicot· 3 shared X. Luo· 3 shared N. Garcia-Seyda· 2 shared A. Farutin· 1 shared A. Hornung· 1 shared A. Michelot· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiophysics

O. Theodoly

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Naive T lymphocytes chemotax to CCL21 but not to S1P-rich serum

N. Garcia Seyda, S. Song, L. David-Broglio, C. Matti, M. Artinger, M. Pelicot-Biarnes, M.-P. Valignat, D. F. Legler, M. Bajenoff, O. Theodoly

This study shows naive T lymphocytes chemotax to CCL21 but not to S1P-rich serum, using in vitro assays to quantify migration responses.

bioRxiv · Feb 3, 2023 · PreprintBiophysics

Mammalian Amoeboid Swimming is propelled by molecular and not protrusion-based paddling in Lymphocytes

L. Aoun, P. Negre, A. Farutin, N. Garcia-Seyda, M. S. Rivzi, R. Galland, A. Michelot, X. Luo, M. Biarnes-Pelicot, C. Hivroz, S. Rafai, J.-B. Sibareta, M.-P. Valignat, C. Misbah, O. Theodoly

This study shows that lymphocytes swim using molecular paddling rather than protrusion-based movement, with propulsion driven by inhomogeneous treadmilling of the cell envelope.

bioRxiv · Jan 2, 2019 · PreprintBiophysics

Different integrins mediate haptotaxis of T lymphocytes towards either lower or higher adhesion zones

X. Luo, L. Aoun, M. Biarnes-Pelicot, P.-O. Strale, V. Studer, M.-P. Valignat, O. Theodoly

This study shows that different integrins guide T lymphocytes toward either higher or lower adhesion zones through haptotaxis, without mechanotransduction.

bioRxiv · Jan 2, 2019 · PreprintBiophysics

A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes

A. Hornung, T. Sbarrato, N. Garcia-Seyda, L. Aoun, X. Luo, M. Biarnes-Pelicot, O. Theodoly, M.-P. Valignat

The paper shows that leukocytes use a bistable mechanism involving integrins LFA-1 and VLA-4 to decide their direction in response to flow.

bioRxiv · Dec 31, 2018Biophysics