Nigratine as first-in-class dual inhibitor of necroptosis and ferroptosis regulated cell death
C. DELEHOUZE, A. COMTE, M. HAUTEVILLE, P. G. GOEKJIAN, M.-T. DIMANCHE-BOITREL, M. ROUSSELOT, S. BACH
This study identifies nigratine as a first-in-class dual inhibitor of necroptosis and ferroptosis, showing efficacy against both cell death pathways with sub-micromolar EC50 values.
bioRxiv · Dec 15, 2020 · PreprintBiochemistry