P2Y12-P-Selectin Mediated Platelet Activation Drives Dengue-Associated Thrombocytopenia
Viviane Lima Batista, Jenniffer Ramos Martins, Angélica Samer Lallo Dias, Talita Cristina Martins da Fonseca, LUISA CONY AYRES DE MIRANDA PEREIRA SALUSTIANO DA SILVA, Felipe Emanuel Oliveira Rocha, Pedro Augusto Carvalho Costa, Wallison Nunes da Silva, Jessica Aparecida Barsalini Pereira, M.A. Antunes, Pedro Pires Goulart Guimarães, Gustavo Batista Menezes, Adriano de Paula Sabino, Lirlandia Pires Sousa, Celso Martins Queiroz‐Junior, , Vivian Vasconcelos Costa
This study shows DENV causes thrombocytopenia through impaired megakaryopoiesis and P-selectin-mediated platelet activation, with potential therapeutic targets identified.
bioRxiv · Sep 8, 2025 · PreprintImmunology