Vivian Vasconcelos Costa

CORONAVIRUS INFECTION ACCELERATES EXPERIMENTAL OSTEOPOROSIS THROUGH THE ACTIVATION OF OSTEOCLASTS

This study shows that coronavirus infection accelerates bone loss in mice with osteoporosis by increasing osteoclast activity and inflammation.

PI3Kγ pathway contributes to neuroinflammation and neuronal death induced by Zika virus infection

This study investigates the role of the PI3Kγ pathway in ZIKV-induced neuroinflammation and neuronal death, finding that its inhibition reduces viral replication and neuroinflammatory responses.

Annexin A1 as a key modulator of lung inflammation during coronavirus infections

This study investigates the role of Annexin A1 in coronavirus-induced lung inflammation and shows that its mimetic peptide Ac2-26 reduces lung damage and lethality in SARS-CoV-2 infection.

P2Y12-P-Selectin Mediated Platelet Activation Drives Dengue-Associated Thrombocytopenia

This study shows DENV causes thrombocytopenia through impaired megakaryopoiesis and P-selectin-mediated platelet activation, with potential therapeutic targets identified.

Cyclodextrin-Based Delivery of the Annexin A1 Mimetic Peptide Ac2-26 Enhances Anti-Inflammatory Effects and PreventsDengue-Induced Lethality in Combination with AntiviralTherapy

This study shows that cyclodextrin-based delivery of the anti-inflammatory peptide Ac2-26 improves survival in dengue-infected mice when combined with antiviral therapy.

Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice

This study establishes a sex-dependent mouse model of post-COVID syndrome, showing neuropsychiatric and musculoskeletal complications in females that are prevented by ovariectomy.

Broad-Spectrum Antiviral Efficacy of 7-Deaza-7-Fluoro-2'-C-Methyladenosine Against Multiple Coronaviruses In Vitro and In Vivo

This study evaluates DFMA's antiviral efficacy against multiple coronaviruses in vitro and in vivo, showing significant reductions in viral load and inflammation across different models.