Author

M.E. Goldstein

Institute for Bioscience and Biotechnology Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Betty ChuiD· 1 shared E.A. Toth· 1 shared John P. OrbaniD· 1 shared K.J. Carillo· 1 shared Thomas R. FuerstiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Betty ChuORCID

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1 paper

Recent·Most cited

Engineered subtilisin protease degrades active KRAS in cancer cells, leading to differential cell targeting

M.E. Goldstein, Betty Chu, K.J. Carillo, John P. Orban, E.A. Toth, Thomas R. Fuerst

This paper demonstrates that engineered RASProtease degrades active KRAS in cancer cells, leading to reduced MEK-ERK signaling and significant cell death in KRAS-dependent MIA PaCa-2 cells.

bioRxiv · Mar 6, 2026 · PreprintCancer Biology