Author

Betty Chu

Institute for Bioscience and Biotechnology ResearchORCID 0000-0002-9429-8893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

John P. OrbaniD· 2 shared E.A. Toth· 1 shared Eric A. TothiD· 1 shared K.J. Carillo· 1 shared M.E. Goldstein· 1 shared Thomas R. FuerstiD· 1 shared Yanan HeiD· 1 shared Yihong CheniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

John P. OrbanORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 6, 2026

Engineered subtilisin protease degrades active KRAS in cancer cells, leading to differential cell targeting

M.E. Goldstein, Betty Chu, K.J. Carillo…·Thomas R. Fuerst

This paper demonstrates that engineered RASProtease degrades active KRAS in cancer cells, leading to reduced MEK-ERK signaling and significant cell death in KRAS-dependent MIA PaCa-2 cells.

1 citation

humanproteomics

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BiochemistrybioRxivPreprintJan 15, 2026

Substrate specificity in a designed RAS-targeting protease is coupled to active site and distal motions

Betty Chu, Yanan He, Yihong Chen…·John P. Orban

This paper shows how substrate specificity in a designed RAS-targeting protease is linked to active site and distal motions, revealing mechanisms for enhanced specificity.

1 citation

experimental assay

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