SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells
Noa Nashnaz, Dana Tamar Goldberg, Maayan Bat-Chen Abramov, Anand Chopra, Tamar Rosiecki, Habib Muallem, Yulia Haim, Tzofit Elbaz Biton, Liron Levin, Raz Zarivach, Michal Feldman, Assaf Rudich, Dan Levy
The paper identifies a feedback loop between SETD6-mediated methylation of PPARγ and lipid metabolism gene expression in liver-derived cells, linking it to lipid accumulation and disease.
eLife · Aug 17, 2026Peer-reviewedCell Biology